Unfortunately (just a very quick test) I get the same error message (but with "-2147024809" this time).
Let me know if any information could be helpful.
Same on the second machine (much less devices attached, G25 again).
If I just use "Send effect" with the startup values (10000|-1|0|0|-1 & 5000 & 0)
I get "Cannot create effect. E_INVALDARG: An invalid par. (...) -21470248)"
I'd be very thankful if you could have another look at some point. Maybe you could revisit your todo list as well