All that you need is to found the ClickID of the "Sav layout" button if i'm right.
At this point, you jsut need to make an empty button with this ClickID and the "save" button will not appear because he already exist.
Anyway, it's easy to counter that by doing SHIFT+I to clear all external program buttons.
So you need to remake this button if the player press SHIFT+I
edit : check SHIFT+B too. i'm not sure about his fucntion so take a look too.