SoftTH needs 3 monitors to run, nVidia used to have a span mode in WinXP but it seems to have been removed (due to it not working in Vista/Win7) which is frustrating.
ATi have a span mode too (for all 3 OSes), seems that nVidia are to slack to try & get this feature working in Vista/Win7.
There is also some hardware out there that allows you to run more monitors off a single port (Matrox one seems to be the best) but they can be expensive.
Here's hoping that nVidia add this feature back in (I run 2 monitors & have an nVidia card) but it's not likely as it's been like this since Vista. Been using nVidia cards for years, but looks like I'll have to change to ATi.