Make sure that in Options > Controls > Axes/FF, the option "Calibration Lock" is set to "No". Then actually rotate the wheel lock to lock. You might also have to press each pedal fully to calibrate them correctly.
Depends, if you set WTC to 1.0 and the steering lock to 720 degrees in both the profiler and LFS, you will have correct lock in every car, but only get FFB lock stops in the road cars. If the lock stops are important to you, and you can be bothered with the hassle, then you need to change the profiler lock everytime you change car.