Depends where you're driving really.
The biggest problem I had in France (Paris to be exact), a few weeks ago (the first time I've ever driven on the wrong side as well), was that there are different rules on the road, in comparison with the UK at least. The law of the road appears to be you have to avoid the crash, especially if you have right of way - if not then it's your fault. Scraps aren't accidents either. Bikers/mopeds/etc are also high and have suicidal tendencies and drive up the middle of the motorway, hazards on, on the pavement.. basically everywhere to get through. There also appears to be no belief in the existance of roundabouts, almost everywhere merges on the main network around Paris. I think I only saw about 2 roundabouts whilst I was there.
If you're driving alone then you seriously need satnav. I tried navigating without, by myself. This was mentally stupid. If you're even half capable of driving a car, then being on the "wrong side" shouldn't bother you in the least, though navigating at the same time is "tricky"
I did find myself giving people a bit of an extra wide berth though... Guess that's what the excess can do to you though..
One thing I should point out was that I was driving around on the Friday before the rugby world cup, at the height of the public transportation strike, so my experiences maybe worse than "normal" for Paris.
Also, if you're coming into Charles De Gaulle Terminal 3, then I suggest you wear some comfy shoes as there's a bit of a walk from the terminal to the train station, which takes you to the main buildings / terminal 1 and 2