You cannot predict the unexpected. I have seen a lot of nasty wrecks because a tyre let go, the last crash was because the driver didn't see some debris on the road which ripped off the whole front right quarter, sending him uncontrollably off the road.
I have no idea what caused him to not notice the debris, but all it takes is a small lapses of concentration and you find yourself under the wheels of a lorry.
Chances are you'll cover hundreds of thousands of miles and nothing goes wrong. But look at it like this, the guys in bomb squads can get lucky and defuse hundreds if not thousands of bombs without issue. Some will turn into pink mist first time in the field. It is dangerous business and you cannot predict what will happen.