No difference in whether you use auto clutch or manual or blip or whatever. Personally I use sequential paddles but then I drive the FOX most of the time or the FO8. In these cars you cannot down change quick enough with manual clutch and H shift because of the characteristics of these cars. This means I lose a lot of time in braking areas when using manual config.
In road cars the penalty is not so great as you don't knock off speed so fast in the braking areas. However, I am still faster with sequential paddles and auto clutch than without.
In some motorsport here in the UK if you have a sequential box it is considered a huge advantage and you are moved up a class - a bit like having a turbo.